In some cases, people pick on one skill (or the combo of a class) and build around it.
Some people pick on heals, then they may get all the skills with heals.
Some people pick on shields, then they may get all the skills with shields.
Some people pick on freeze, then they may get all the frozen skills.
Some people pick on cloak, then they may build around that.
Some people pick on one big shot, then they build around in combination of another skill set.
Some people pick a skill that increase the level of other skills (nerfed), then they may build around in combination of another skill set.
When you start with a skill or set of skills, and realize it does not work (or nerfed), then you start all over to look at other skills to see if you can build around with it.
Perhaps look for a skill or two that you like, and start thinking how you can build around it.